(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Cells can respond to stress in various ways ranging from the activation of survival pathways
to the initiation of cell death that eventually eliminates damaged cells. Whether cells mount a …

Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

Cardiovascular disease is the leading cause of death worldwide. As such, there is great
interest in identifying novel mechanisms that govern the cardiovascular response to disease …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

There remains an unmet need to identify novel therapeutic strategies capable of protecting
the myocardium against the detrimental effects of acute ischemia–reperfusion injury (IRI), to …

Covering: 2004 to 2006 Natural products have provided considerable value to the
pharmaceutical industry over the past half century. In particular, the therapeutic areas of …

The mTOR pathway has a central role in the regulation of cell metabolism, growth and
proliferation. Studies involving selective gene targeting of mTOR complexes (mTORC1 and …

Autophagy, an intracellular bulk degradation process of cellular constituents, plays a key
role in cell homeostasis and can be induced by stresses, such as nutrient depletion, closed …

Aims The present study was designed to examine the mechanism involved in mitochondrial
aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion …