Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial–mesenchymal transition
W Jin - Cells, 2020 - mdpi.com
The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …
The multifaced role of STAT3 in cancer and its implication for anticancer therapy
M Tolomeo, A Cascio - International journal of molecular sciences, 2021 - mdpi.com
Signal transducer and activator of transcription (STAT) 3 is one of the most complex
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …
regulators of transcription. Constitutive activation of STAT3 has been reported in many types …
Terpenoids: natural products for cancer therapy
Introduction: Terpenoids constitute the largest class of natural products and are a rich
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …
Growth hormone's links to cancer
CL Boguszewski, MCS Boguszewski - Endocrine reviews, 2019 - academic.oup.com
Several components of the GH axis are involved in tumor progression, and GH-induced
intracellular signaling has been strongly associated with breast cancer susceptibility in …
intracellular signaling has been strongly associated with breast cancer susceptibility in …
Long noncoding RNA NEAT1 drives aggressive endometrial cancer progression via miR-361-regulated networks involving STAT3 and tumor microenvironment …
P Dong, Y Xiong, J Yue, D Xu, K Ihira, Y Konno… - Journal of Experimental …, 2019 - Springer
Background High-grade endometrioid and serous endometrial cancers (ECs) are an
aggressive subtype of ECs without effective therapies. The reciprocal communication …
aggressive subtype of ECs without effective therapies. The reciprocal communication …
Biological activities and potential molecular targets of cucurbitacins: a focus on cancer
Cucurbitacin and its derivatives (cucurbitacins) are a class of highly oxidized tetracyclic
triterpenoids. They are widely distributed in the plant kingdom, where they act as …
triterpenoids. They are widely distributed in the plant kingdom, where they act as …
Transcription factors in cancer: when alternative splicing determines opposite cell fates
S Belluti, G Rigillo, C Imbriano - Cells, 2020 - mdpi.com
Alternative splicing (AS) is a finely regulated mechanism for transcriptome and proteome
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …
diversification in eukaryotic cells. Correct balance between AS isoforms takes part in …
[HTML][HTML] STAT3 isoforms: Alternative fates in cancer?
P Aigner, V Just, D Stoiber - Cytokine, 2019 - Elsevier
Signal transducer and activator of transcription (STAT) 3 is the main mediator of IL-6-type
cytokine signaling and an important transcriptional regulator of cell proliferation, maturation …
cytokine signaling and an important transcriptional regulator of cell proliferation, maturation …
Autocrine/paracrine human growth hormone-stimulated MicroRNA 96-182-183 cluster promotes epithelial-mesenchymal transition and invasion in breast cancer
Human growth hormone (hGH) plays critical roles in pubertal mammary gland growth,
development, and sexual maturation. Accumulated studies have reported that …
development, and sexual maturation. Accumulated studies have reported that …