Abstract The MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide)
tetrazolium assay is a popular tool in estimating the metabolic activity of living cells. The test …

Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Objectives To develop simple, rapid, low-cost and robust assays for screening drugs against
dormant and actively growing mycobacteria. Methods Actively growing aerobic and hypoxia …

Therapeutic options for tuberculosis (TB) are limited and notoriously ineffective despite the
wide variety of potent antibiotics available for treating other bacterial infections. We …

Avermectins are a family of macrolides known for their anthelmintic activities and
traditionally believed to be inactive against all bacteria. Here we report that members of the …

Toxicity testing of nanomaterials (NMs) is experimentally challenging because NMs may
interfere with test environment and assay components. In this work we propose a simple and …

Objectives: With the spread of multidrug-resistant tuberculosis (MDR-TB) there is increasing
demand for new accurate and cost-effective tools for rapid drug susceptibility testing (DST) …

While modern cephalosporins developed for broad spectrum antibacterial activities have
never been pursued for tuberculosis (TB) therapy, we identified first generation …

Background Mutations associated with resistance to rifampin or streptomycin have been
reported for W/Beijing and Latin American Mediterranean (LAM) strain families of …

The lack of effective therapies for treating tuberculosis (TB) is a global health problem. While
Mycobacterium tuberculosis is notoriously resistant to most available antibiotics, we …