Biology of GDNF and its receptors—relevance for disorders of the central nervous system
CF Ibáñez, JO Andressoo - Neurobiology of disease, 2017 - Elsevier
A targeted effort to identify novel neurotrophic factors for midbrain dopaminergic neurons
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …
resulted in the isolation of GDNF (glial cell line-derived neurotrophic factor) from the …
Intracellular RET signaling pathways activated by GDNF
K Kawai, M Takahashi - Cell and tissue research, 2020 - Springer
Activation of RE arranged during T ransfection (RET) proto-oncogene is responsible for
various human cancers such as papillary and medullary thyroid carcinomas and non-small …
various human cancers such as papillary and medullary thyroid carcinomas and non-small …
RET receptor tyrosine kinase: role in neurodegeneration, obesity, and cancer
AK Mahato, YA Sidorova - International journal of molecular sciences, 2020 - mdpi.com
Rearranged during transfection (RET) is the tyrosine kinase receptor that under normal
circumstances interacts with ligand at the cell surface and mediates various essential roles …
circumstances interacts with ligand at the cell surface and mediates various essential roles …
Neural glycosylphosphatidylinositol-anchored proteins in synaptic specification
Glycosylphosphatidylinositol (GPI)-anchored proteins are a specialized class of lipid-
associated neuronal membrane proteins that perform diverse functions in the dynamic …
associated neuronal membrane proteins that perform diverse functions in the dynamic …
Targeting rearranged during transfection in cancer: A perspective on small-molecule inhibitors and their clinical development
D Saha, KR Ryan, NR Lakkaniga… - Journal of medicinal …, 2021 - ACS Publications
Rearranged during transfection (RET) is a receptor tyrosine kinase essential for the normal
development and maturation of a diverse range of tissues. Aberrant RET signaling in …
development and maturation of a diverse range of tissues. Aberrant RET signaling in …
Growth factors and alcohol use disorder
M Liran, N Rahamim, D Ron… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
Neurotrophic growth factors were originally characterized for their support in neuronal
differentiation, outgrowth, and survival during development. However, it has been …
differentiation, outgrowth, and survival during development. However, it has been …
RET-independent signaling by GDNF ligands and GFRα receptors
CF Ibáñez, G Paratcha, F Ledda - Cell and tissue research, 2020 - Springer
The discovery in the late 1990s of the partnership between the RET receptor tyrosine kinase
and the GFRα family of GPI-anchored co-receptors as mediators of the effects of GDNF …
and the GFRα family of GPI-anchored co-receptors as mediators of the effects of GDNF …
Sigma–1 receptor activation alleviates blood–brain barrier disruption post cerebral ischemia stroke by stimulating the GDNF–GFRα1–RET pathway
D Liu, L Yang, P Liu, X Ji, X Qi, Z Wang, T Chi… - Experimental …, 2022 - Elsevier
Blood–brain barrier (BBB) disruption is one of the most important pathological
manifestations of ischemic stroke. Reducing BBB collapse is effective in alleviating brain …
manifestations of ischemic stroke. Reducing BBB collapse is effective in alleviating brain …
Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytes
Perfluorooctanesulfonate (PFOS) is a man-made chemical widely used in industrial
products. Due to its high persistence, PFOS has been detected in most animal species …
products. Due to its high persistence, PFOS has been detected in most animal species …
Identification of GPI-anchored protein LYPD1 as an essential factor for odontoblast differentiation in tooth development
Y Fu, K Miyazaki, Y Chiba, K Funada, T Yuta… - Journal of Biological …, 2023 - ASBMB
Lipid rafts are membrane microdomains rich in cholesterol, sphingolipids,
glycosylphosphatidylinositol-anchored proteins (GPI-APs), and receptors. These lipid raft …
glycosylphosphatidylinositol-anchored proteins (GPI-APs), and receptors. These lipid raft …