Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

Macroautophagy decreases with age, and this change is considered a hallmark of the aging
process. It remains unknown whether mitophagy, the essential selective autophagic …

Mitochondria are key orchestrators of antiviral responses that serve as platforms for the
assembly and activation of innate immune-signaling complexes. In response to viral …

Mutations that increase LRRK2 kinase activity have been linked to Parkinson's disease and
Crohn's disease. LRRK2 is also activated by lysosome damage. However, the endogenous …

Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of
mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to …

Loss-of-function variants in the PRKN gene encoding the ubiquitin E3 ligase PARKIN cause
autosomal recessive early-onset Parkinson's disease (PD). Extensive in vitro and in vivo …

Simple Summary Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis
(ALS), Alzheimer's disease (AD), and Parkinson's disease (PD), mainly impact the central …

The prevalence of age-related neurodegenerative diseases, such as Parkinson's disease
(PD) and related disorders continues to grow worldwide. Increasing evidence links …

Pattern recognition receptors (PRRs) recognize danger signals such as PAMPs/MAMPs and
DAMPs to initiate a protective immune response. TLRs, NLRs, CLRs, and RLRs are well …

Summary cGAS-like receptor (cGLR)-stimulator of interferon genes (STING) recently
emerged as an important pathway controlling viral infections in invertebrates. However, its …