The goal of this review is to summarize studies in which concentrations of circulating
endocannabinoids in humans have been examined in relationship to physiological …

The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …

There are at least 2 types of cannabinoid receptor, CB 1 and CB 2, both G protein coupled.
CB 1 receptors are expressed predominantly at nerve terminals and mediate inhibition of …

The endocannabinoid signaling system is a widespread, neuromodulatory system in brain
and is also widely utilized in the periphery to modulate metabolic functions and the immune …

Endocannabinoids are lipid mediators of the same cannabinoid (CB) receptors that mediate
the effects of marijuana. The endocannabinoid system (ECS) consists of CB receptors …

Liver cirrhosis is associated with several cardiovascular abnormalities. Despite an increased
baseline cardiac output, cirrhotic patients have a suboptimal ventricular response to stress …

A multitude of physiological effects and putative pathophysiological roles have been
proposed for the endogenous cannabinoid system in the gastrointestinal tract, liver and …

In liver cirrhosis, abnormal persistent extrahepatic vasodilation leads to hyperdynamic
circulatory dysfunction which essentially contributes to portal hypertension. Since portal …

The endocannabinoids anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl
glycerol (2AG) are physiologically occurring, biologically active compounds on CB1 and …

Although used for more than 4000 years for recreational and medicinal purposes, Cannabis
and its best-known pharmacologically active constituents, the cannabinoids, became a …