Fibro-adipogenic progenitors (FAPs) are typically activated in response to muscle injury, and
establish functional interactions with inflammatory and muscle stem cells (MuSCs) to …

Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by
cellular alterations such as increased plasma membrane permeability, reduced resting …

Circular RNAs (circRNAs) are a special class of recently re‑discovered RNAs, which are
covalently closed ring RNA molecules. circRNAs have been reported to possess multiple …

The importance of precise co-and post-transcriptional processing of RNA in the regulation of
gene expression has become increasingly clear. RNA-binding proteins (RBPs) are a class …

Background G protein-coupled receptors (GPCRs) participate in a variety of physiologic
functions, and several GPCRs have critical physiologic and pathophysiologic roles in the …

Most neurodegenerative disorders are associated with accumulation of disease-relevant
proteins. Among them, Huntington disease (HD) is of particular interest because of its …

Background Aging-related strength decline contributes to physiological deterioration and is
a good predictor of poor prognosis. However, the mechanisms underlying neuromuscular …

Progressive weakness is a typical feature of Duchenne muscular dystrophy (DMD) patients
and is exacerbated in the benign mdx mouse model by in vivo treadmill exercise. We …

The coordination of food intake, energy storage, and expenditure involves complex
interactions between hypothalamic neurons and peripheral tissues including pancreatic …

The collagen ColQ anchors acetylcholinesterase (AChE) in the synaptic cleft of the
neuromuscular junction (NMJ). It also binds MuSK and perlecan/dystroglycan, 2 signaling …