New pathways identify novel drug targets for the prevention and treatment of Alzheimer's disease

B Penke, M Szűcs, F Bogár - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is an incurable, progressive neurodegenerative disorder. AD is a
complex and multifactorial disease that is responsible for 60–80% of dementia cases. Aging …

Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy

A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …

Nanotheranostic: The futuristic therapy for copper mediated neurological sequelae

A Mhaske, S Sharma, R Shukla - Journal of Drug Delivery Science and …, 2023 - Elsevier
Copper (Cu) is contemplated as an indispensable metal with an exquisite role in nerve
conduction, mitochondrial ATP synthesis, neurotransmitter synthesis and antioxidant activity …

Why the Ala-His-His Peptide Is an Appropriate Scaffold to Remove and Redox Silence Copper Ions from the Alzheimer's-Related Aβ Peptide

P Gonzalez, L Sabater, E Mathieu, P Faller, C Hureau - Biomolecules, 2022 - mdpi.com
The progressive, neurodegenerative Alzheimer's disease (AD) is the most widespread
dementia. Due to the ageing of the population and the current lack of molecules able to …

Establishment of a Labile Bound Copper Reference Interval in a Healthy Population via an Inductively Coupled Plasma Mass Spectrometry Dual Filtration–Based …

AC Bitzer, J Fox, PL Day… - … of Pathology & …, 2024 - meridian.allenpress.com
Context.—Clinical testing for Wilson disease (WD) is potentially challenging. Measuring the
fraction of labile bound copper (LBC) to total copper may be a promising alternative …

Sequence–Activity Relationship of ATCUN Peptides in the Context of Alzheimer's Disease

M Lefèvre, KP Malikidogo, C Esmieu, C Hureau - Molecules, 2022 - mdpi.com
Amino-terminal CuII and NiII (ATCUN) binding sequences are widespread in the biological
world. Here, we report on the study of eight ATCUN peptides aimed at targeting copper ions …

Copper aggravated synaptic damage after traumatic brain injury by downregulating BNIP3-mediated mitophagy

H Chang, W Zhang, L Xu, Z Li, C Lin, Y Shen… - Autophagy, 2024 - Taylor & Francis
Synaptic damage is a crucial pathological process in traumatic brain injury. However, the
mechanisms driving this process remain poorly understood. In this report, we demonstrate …

[HTML][HTML] Involvement of the inhibition of mitochondrial apoptotic, p53, NF-κB pathways and the activation of Nrf2/HO-1 pathway in the protective effects of curcumin …

C Dai, M Li, Y Liu, DH Tran, H Jiang, S Tang… - … and Environmental Safety, 2023 - Elsevier
Chronic copper exposure could cause potential nephrotoxicity and effective therapy
strategies are limited. This study investigated the protective effects of curcumin on copper …

[HTML][HTML] Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation

D Hao, W Luo, Y Yan, J Zhou - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Cuproptosis is a novel form of regulated cell death, which plays an important role in the
physiological and pathological processes of the human body. Despite the increasing …

Exploring the Antioxidant Potential of Talisia esculenta Using In Vitro and In Vivo Approaches

ML da Silva Cordeiro, VG de Queiroz Aquino-Martins… - Nutrients, 2023 - mdpi.com
Medicinal plants, such as Talisia esculenta, are rich in antioxidant biomolecules, which are
used in the treatment and prevention of many diseases. The antioxidant potential of T …