Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
SM Stanford, N Bottini - Nature Reviews Drug Discovery, 2023 - nature.com
Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …
attractive therapeutic targets for various diseases. Although extensive effort has been …
[HTML][HTML] Redox active or thiol reactive? Optimization of rapid screens to identify less evident nuisance compounds
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are
routinely encountered in assays at various stages of drug discovery. We observed that …
routinely encountered in assays at various stages of drug discovery. We observed that …
PRL3 pseudophosphatase activity is necessary and sufficient to promote metastatic growth
Phosphatases of regenerating liver (PRLs) are markers of cancer and promote tumor
growth. They have been implicated in a variety of biochemical pathways but the …
growth. They have been implicated in a variety of biochemical pathways but the …
[HTML][HTML] Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis
H Zhang, N Li, Y Zhang, Y Xu, F Lu, D Lin, S Lin, M Li… - Biomedicines, 2024 - mdpi.com
Chemotherapy is an important factor leading to male infertility. It is crucial to discover safe
and effective treatments to prevent male reproductive injury caused by chemotherapy. The …
and effective treatments to prevent male reproductive injury caused by chemotherapy. The …
The double lives of phosphatases of regenerating liver: A structural view of their catalytic and noncatalytic activities
Phosphatases of regenerating liver (PRLs) are protein phosphatases involved in the control
of cell growth and migration. They are known to promote cancer metastasis but, despite over …
of cell growth and migration. They are known to promote cancer metastasis but, despite over …
Development of a high-throughput screening system targeting the protein-protein interactions between PRL and CNNM
Y Funato, M Mimura, K Nunomura, B Lin, S Fujii… - Scientific Reports, 2024 - nature.com
Phosphatase of regenerating liver (PRL) is an oncogenic protein that promotes tumor
progression by directly binding to cyclin M (CNNM) membrane proteins and inhibiting their …
progression by directly binding to cyclin M (CNNM) membrane proteins and inhibiting their …
[HTML][HTML] The emerging roles and therapeutic potential of cyclin M/CorC family of Mg2+ transporters
Cyclin M (CNNM) and its prokaryotic ortholog CorC belong to a family of proteins that
function as Mg 2+-extruding transporters by stimulating Na+/Mg 2+ exchange, and thereby …
function as Mg 2+-extruding transporters by stimulating Na+/Mg 2+ exchange, and thereby …
Phosphatase‐independent role of phosphatase of regenerating liver in cancer progression
Phosphatase of regenerating liver (PRL) is a family of protein tyrosine phosphatases (PTPs)
that are anchored to the plasma membrane by prenylation. They are frequently …
that are anchored to the plasma membrane by prenylation. They are frequently …
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors
NR Tasker, EJ Rastelli, JC Burnett, ER Sharlow… - Bioorganic & medicinal …, 2019 - Elsevier
Protein tyrosine phosphatases (PTPs) are emerging new targets for drug discovery. PTPs
and protein tyrosine kinases (PTKs) maintain cellular homeostasis through opposing roles …
and protein tyrosine kinases (PTKs) maintain cellular homeostasis through opposing roles …
Targeting Moonlighting Enzymes in Cancer
C Lin, M Yu, X Wu, H Wang, M Wei, L Zhang - Molecules, 2024 - mdpi.com
Moonlighting enzymes are multifunctional proteins that perform multiple functions beyond
their primary role as catalytic enzymes. Extensive research and clinical practice have …
their primary role as catalytic enzymes. Extensive research and clinical practice have …