This review critically summarizes the neuropathology and genetics of schizophrenia, the
relationship between them, and speculates on their functional convergence. The …

A number of studies have indicated that antagonists of the N‐methyl‐d‐aspartate subtypes
of glutamate receptors can cause schizophrenia‐like symptoms in healthy individuals and …

d-amino acids, the enantiomeric counterparts of l-amino acids, were long considered to be
non-functional or not even present in living organisms. Nowadays, d-amino acids are …

Peroxisome proliferator-activated and retinoid X receptors (PPARs and RXRs) are
transcription factors belonging to the steroid hormone receptor superfamily. Upon activation …

We report a unique mutation in the D-amino acid oxidase gene (R199W DAO) associated
with classical adult onset familial amyotrophic lateral sclerosis (FALS) in a three …

Clinical trials demonstrated that d-serine administration improves schizophrenia symptoms,
raising the possibility that altered levels of endogenous d-serine may contribute to the N …

The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that
are more reactive than O 2 itself, which include hydrogen peroxide and superoxide …

Oxidative stress, a state of disrupted redox signaling, reactive oxygen species (ROS)
overproduction, and oxidative cell damage, accompanies numerous brain pathologies …

Recent evidence has shown that d-amino acids are present in animals and humans in high
concentrations and fulfill specific biological functions. In the central nervous system, two d …

D-Amino acid oxidase (DAAO) is an FAD-containing flavoenzyme that catalyzes with
absolute stereoselectivity the oxidative deamination of all natural D-amino acids, the only …