Ready for repair? Gene editing enters the clinic for the treatment of human disease
MPT Ernst, M Broeders, P Herrero-Hernandez… - … Therapy Methods & …, 2020 - cell.com
We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …
[HTML][HTML] Linking gut microbiota to colorectal cancer
H Raskov, J Burcharth, HC Pommergaard - Journal of cancer, 2017 - ncbi.nlm.nih.gov
Pre-clinical and clinical data produce mounting evidence that the microbiota is strongly
associated with colorectal carcinogenesis. Dysbiosis may change the course of …
associated with colorectal carcinogenesis. Dysbiosis may change the course of …
NCCN guidelines® insights: Ovarian cancer, version 3.2022: Featured updates to the NCCN guidelines
DK Armstrong, RD Alvarez, FJ Backes… - Journal of the National …, 2022 - jnccn.org
Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the
United States, with less than half of patients living> 5 years following diagnosis. The NCCN …
United States, with less than half of patients living> 5 years following diagnosis. The NCCN …
NCCN guidelines insights: non–small cell lung cancer, version 5.2018
The NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC) address all aspects of
management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the …
management for NSCLC. These NCCN Guidelines Insights focus on recent updates to the …
Safety profile of baricitinib in patients with active rheumatoid arthritis with over 2 years median time in treatment
JS Smolen, MC Genovese, T Takeuchi… - The Journal of …, 2019 - jrheum.org
Objective. Baricitinib is an oral, once-daily selective Janus kinase (JAK1/JAK2) inhibitor for
adults with moderately to severely active rheumatoid arthritis (RA). We evaluated baricitinib's …
adults with moderately to severely active rheumatoid arthritis (RA). We evaluated baricitinib's …
[HTML][HTML] Risk factors for early-onset colorectal cancer
Background & Aims Colorectal cancer (CRC) incidence and mortality are increasing among
persons younger than 50 years old in the United States, but risk factors associated with early …
persons younger than 50 years old in the United States, but risk factors associated with early …
Arterial thromboembolic events preceding the diagnosis of cancer in older persons
Cancer patients face an increased risk of arterial thromboembolism; however, it is uncertain
when this excess risk begins. This study evaluated the risk of arterial thromboembolism …
when this excess risk begins. This study evaluated the risk of arterial thromboembolism …
Association of chemotherapy for solid tumors with development of therapy-related myelodysplastic syndrome or acute myeloid leukemia in the modern era
Importance Therapy-related myelodysplastic syndrome or acute myeloid leukemia
(tMDS/AML) is a rare, usually fatal complication of chemotherapy, including certain …
(tMDS/AML) is a rare, usually fatal complication of chemotherapy, including certain …
[HTML][HTML] Overview of current concepts in gastric intestinal metaplasia and gastric cancer
DS Jencks, JD Adam, ML Borum, JM Koh… - Gastroenterology & …, 2018 - ncbi.nlm.nih.gov
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with
intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The …
intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The …
Immuno-transcriptomic profiling of extracranial pediatric solid malignancies
We perform an immunogenomics analysis utilizing whole-transcriptome sequencing of 657
pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally …
pediatric extracranial solid cancer samples representing 14 diagnoses, and additionally …