Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

In subjects with schizophrenia, impairments in working memory are associated with
dysfunction of the dorsolateral prefrontal cortex (DLPFC). This dysfunction appears to be …

There is substantial evidence that GABAergic neurotransmission is important for many
behavioral actions of ethanol and there are reports spanning more than 30 years of literature …

The excitatory synapse between hippocampal CA3 and CA1 pyramidal neurons exhibits
long-term potentiation (LTP), a positive feedback process implicated in learning and memory …

Ionotropic GABA transmission is mediated by anion (mainly Cl−)-permeable GABAA
receptors (GABAARs). In immature neurons, GABA exerts depolarizing and sometimes …

According to the rules of GABAA receptor (GABAAR) subunit assembly, α4 and α6 subunits
are considered to be the natural partners of δ subunits. These GABAARs are a preferred …

Since 1996, nearly 100 genes have been studied for their effects related to ethanol in mice
using genetic modifications including gene deletion, gene overexpression, gene knock‐in …

A remarkable amount of our current knowledge of mechanisms underlying experience-
dependent plasticity during cortical development comes from study of the mammalian visual …

Recent studies have demonstrated that metabotropic glutamate receptor 5 (mGluR5)
antagonists decrease alcohol self-administration and suggest that the anti-craving …

Exogenously expressed opsins are valuable tools for optogenetic control of neurons in
circuits. A deeper understanding of neural function can be gained by bringing control to …