Somites are the most obvious metameric structures in the vertebrate embryo. They are
mesodermal segments that form in bilateral pairs flanking the notochord and are created …

Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously
replenish all blood and immune cells during the lifetime of an individual,. HSCs are used …

Bone morphogenetic protein (Bmp) signaling has long been known to be important for the
early development of the ventral mesoderm, including blood, vasculature and kidney cells …

Abstract Background α-Synuclein (α-Syn) fibrils are the main constituent of Lewy bodies and
a neuropathological hallmark of Parkinson's disease (PD). The propagation of α-Syn …

Leber congenital amaurosis (LCA) is a severe autosomal‐recessive retinal dystrophy
leading to congenital blindness. A recently identified LCA gene is NMNAT1, located in the …

Background Platelets are small anucleated blood particles that play a key role in the control
of bleeding. Platelets need to be activated to perform their functions and participate in …

Cooperation and aggression are ubiquitous in social groups, and the genetic mechanisms
underlying these behaviours are of great interest for understanding how social group …

Wnt signaling regulates embryonic patterning and controls stem cell homeostasis, while
aberrant Wnt activity is associated with disease. One Wnt family member, Wnt3, is required …

The distal part of 1p is frequently deleted in aggressive neuroblastoma, and the region is
believed to harbor one or more tumor suppressor genes relevant to tumor development. To …

Many protein-coding genes identified by genome sequencing remain without functional
annotation or biological context. Here we define a novel protein-coding gene, Nmf9, based …