Forkhead box protein 3-expressing (FOXP3+) regulatory T cells (Treg cells) suppress
conventional T cells and are essential for immunological tolerance. FOXP3, the master …

Here, we review a novel concept namely the compensatory immune-regulatory reflex system
(CIRS) as applied to the pathophysiology of major depressive disorder (MDD) and bipolar …

The local regulation of type 2 immunity relies on dialog between the epithelium and the
innate and adaptive immune cells. Here we found that alarmin-induced expression of the co …

Atopic dermatitis (AD), a common chronic inflammatory skin disease, is characterized by
inflammatory cell skin infiltration. The JAK-STAT pathway has been shown to play an …

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

Melatonin affects a variety of physiological processes including circadian rhythms, cellular
redox status, and immune function. Importantly, melatonin significantly influences T‐cell …

In recent years, the broadening understanding of the pathogenesis of atopic dermatitis (AD)
has led to the development of novel therapeutic molecules, that target core inflammatory …

Although osteoarthritis (OA) has been traditionally regarded as a non-inflammatory disease,
reports increasingly suggest that it is inflammatory, at least in certain patients. OA patients …

T-cell-mediated immune responses aim to protect mammals against cancers and infections,
and are also involved in the pathogenesis of various inflammatory or autoimmune diseases …

Background Inborn errors of immunity have been implicated in causing immune
dysregulation, including allergic diseases. STAT6 is a key regulator of allergic responses …