The Hippo signaling pathway is an evolutionarily conserved kinase cascade, playing
multiple roles in embryonic development that controls organ size, cell proliferation, and …

The epidermal growth factor receptor (EGFR) is expressed in numerous cell types in the
adult mammalian kidney and is activated by a family of EGF-like ligands. EGFR activation …

Activation of the EGF receptor (EGFR) or the Hippo signaling pathway can control cell
proliferation, apoptosis, and differentiation, and the dysregulation of these pathways can …

Type 2 diabetes mellitus (T2D) is a multifactorial and genetically heterogeneous disease
which leads to impaired glucose homeostasis and insulin resistance. The advanced form of …

Bodily fluids such as cerebrospinal fluid (CSF) and serum can be analysed at the time of
presentation and throughout the course of the disease. Changes in the protein composition …

Post-translational modifications are fundamental to processes controlling behaviour,
including cellular signaling, growth and transformation. As the molecular basis of protein …

Epidermal growth factor receptor inhibition attenuates early kidney enlargement in
experimental diabetes. Background Renal enlargement is an early feature of both human …

Epidermal growth factor (EGF) and transforming growth factor-β1 (TGF-β1), upregulated in
renal diseases, have a combinational effect on epithelial–mesenchymal transformation …

1 In order to characterize the roles of tyrosine kinases (TKs) and epidermal growth factor
receptor (EGFR) in diabetes‐induced vascular dysfunction, we investigated the ability of a …

The Hippo signaling pathway is a vital suppressor of tumorigenesis that is often inactivated
in human cancers. In normal cells, the Hippo pathway is triggered by external forces such as …