The major obstacles observed in current chemotherapy are severe adverse effects, narrow
therapeutic indexes and multidrug resistance. Anticancer phytochemicals are extracted and …

In the current chapter, a new strategic compilation of phytochemicals with potent antitumor
properties has been addressed, most importantly focusing on cell cycle arrest and apoptotic …

Background: Squamous cell carcinoma (SCC) is one of the most common neoplasms
affecting the oral cavity and the face. Its more differentiated forms may be associated with …

Integrating metabolomics and transcriptomics to unveil the spatiotemporal distribution of
macrocyclic diterpenoids and candidate genes involved in ingenol biosynthesis in the medicinal …

Prostratin, a non-tumor promoting 12-deoxyphorbol ester, has been reported as a protein
kinase C (PKC) activator and is shown to have anti-proliferative activity in certain cancer cell …

Key message Based on transport inhibition and genome-wide analysis, 123 ABC
transporters of Euphorbia lathyris were identified, and it was found that the PDR family …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by
autoantibody production by hyper-activated B cells. Although mesenchymal stem cells …

Actinic keratoses (AKs) are epidermal cutaneous neoplasia observed predominantly in
middle-aged and older subjects with mainly photo type I and photo type II on sun-exposed …

Munc13-1 is a presynaptic active zone protein that plays a critical role in priming the
synaptic vesicle and releasing neurotransmitters in the brain. Munc13-1 acts as a scaffold …

Plants are a significant cause of skin reactions worldwide. Because most affected individuals
do not present to a dermatologist, it is likely that skin reactions to plants are under-reported …