The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance
(NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has …

Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …

Introduction: Drug discovery is a challenging endeavor requiring the interplay of many
different research areas. Gathering information on ligand binding thermodynamics may help …

Matrix metalloproteases (MMPs) are the proteolytic enzymes accountable for extracellular
matrix (ECM) modification through their Zn2+-dependent catalytic activity. Among these …

Matrix metalloproteinases (MMPs) are involved in a multitude of severe diseases. Despite
MMPs being considered druggable targets, past drug‐discovery programs have not …

Uncontrolled regulation of specific metalloenzymes plays important roles in several
diseases like tumor metastasis and inflammation. Therefore, selective metalloenzyme …

Isothermal titration calorimeters (ITCs) are thermodynamic instruments used for the
determination of enthalpy changes in any physical/chemical reaction. This can be applied in …

Proteases irreversibly modify proteins by cleaving their amide bonds and are implicated in
virtually every important biological process such as immunity, development and tissue …

The importance of sulphonamide moiety in medicinal chemistry cannot be ignored as it
constitutes an important class of extensively used drugs. Recently, sulphonamides have …