Enantioselective desymmetrisation

MC Willis - Journal of the Chemical Society, Perkin Transactions 1, 1999 - pubs.rsc.org
2.1 Anhydride substrates 2.2 Epoxide and aziridine substrates 2.3 Alkene and diene
substrates 2.4 Diol and polyol substrates 2.5 Miscellaneous substrates 3 Desymmetrisation …

Two-directional synthesis and its use in natural product synthesis

SR Magnuson - Tetrahedron, 1995 - Elsevier
The ways in which acyclic chains are synthesized may often be classified into one of four
strategies (Scheme 1). The classical one directional Linear Synthesis and Convergent …

Organocopper reagents: substitution, conjugate addition, carbo/metallocupration, and other reactions

BH Lipshutz, S Sengupta - Organic Reactions, 2004 - Wiley Online Library
Well over a decade ago, two reviews were contributed to the Organic Reactions series
covering substitution and conjugate addition reactions in organocopper chemistry. Their …

A general, convergent strategy for the construction of indolizidine alkaloids: total syntheses of (−)-indolizidine 223AB and alkaloid (−)-205B

AB Smith, DS Kim - The Journal of Organic Chemistry, 2006 - ACS Publications
N-Toluenesulfonyl aziridines comprise effective second electrophiles in the solvent
controlled three-component linchpin union of silyl dithianes for the stereocontrolled …

Cycloaddition reactions of nitrile oxides with alkenes

CJ Easton, CMM Hughes, GP Savage… - Advances in Heterocyclic …, 1994 - Elsevier
Publisher Summary This chapter reviews the cycloaddition reactions of nitrile oxides with
alkenes. It covers the literature published between 1985 and 1992. The chapter emphasizes …

Synthesis and characterization of triptych μ-ABC star triblock copolymers

Z Li, MA Hillmyer, TP Lodge - Macromolecules, 2004 - ACS Publications
We describe a general procedure for the synthesis of miktoarm star triblock copolymers with
a hydrocarbon, a fluoropolymer, and a hydrophilic segment. Several μ-(polyethylethylene) …

Asymmetric Sharpless epoxidation of divinylcarbinol. Erythro-D-and-L-4-pentenitols by hydrolysis of regioisomeric epoxy-4-pentenols

V Jäger, D Schröter, B Koppenhoefer - Tetrahedron, 1991 - Elsevier
The asymmetric Sharpless epoxidation of divinylcarbinol (1), a secondary, achiral allylic
alcohol, is described in detail. The epoxidation proceeds with high enantio-control and …

A New Synthetic Approach to High‐Purity (15R)‐Latanoprost

JG Martynow, J Jóźwik, W Szelejewski, O Achmatowicz… - 2007 - Wiley Online Library
This paper describes a new synthesis of latanoprost (1) that afforded high purity latanoprost
in 16.9% overall yield in eight synthetic steps from sulfone 4. The “α chain” in a derivative of …

Synthesis of entecavir (BMS-200475)

B Zhou, Y Li - Tetrahedron Letters, 2012 - Elsevier
A synthesis of Entecavir (BMS-200475) was achieved starting from 1, 3-propanediol in 15
steps and 23.4% overall yield. A unique feature of the synthetic route is that the five …

A new chemoenzymatic approach to the synthesis of Latanoprost and Bimatoprost

ML Contente, P Zambelli, S Galafassi… - Journal of Molecular …, 2015 - Elsevier
Abstract Bimatoprost (1) and Latanoprost (2) are prostaglandin analogues widely used for
glaucoma treatment. We have developed a new chemoenzymatic synthesis for 1 and 2 …