Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

Monoclonal antibody therapies against SARS-CoV-2

D Focosi, S McConnell, A Casadevall… - The Lancet Infectious …, 2022 - thelancet.com
Monoclonal antibodies (mAbs) targeting the spike protein of SARS-CoV-2 have been widely
used in the ongoing COVID-19 pandemic. In this paper, we review the properties of mAbs …

Estimated effectiveness of COVID-19 vaccines against Omicron or Delta symptomatic infection and severe outcomes

SA Buchan, H Chung, KA Brown, PC Austin… - JAMA network …, 2022 - jamanetwork.com
Importance The incidence of SARS-CoV-2 infection, including among individuals who have
received 2 doses of COVID-19 vaccine, increased substantially following the emergence of …

Signals of significantly increased vaccine breakthrough, decreased hospitalization rates, and less severe disease in patients with coronavirus disease 2019 caused by …

PA Christensen, RJ Olsen, SW Long, R Snehal… - The American journal of …, 2022 - Elsevier
Genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
continue to dramatically alter the landscape of the coronavirus disease 2019 (COVID-19) …

Sensitivity of the SARS-CoV-2 BA. 2.86 variant to prevailing neutralising antibody responses

DJ Sheward, Y Yang, M Westerberg, S Öling… - The Lancet Infectious …, 2023 - thelancet.com
SARS-CoV-2 lineages, a substantially mutated sublineage of BA. 2 has recently emerged.
Designated BA. 2.86, 1 the geographic origin of this sublineage is currently unclear and, as …

Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

JM Taft, CR Weber, B Gao, RA Ehling, J Han, L Frei… - Cell, 2022 - cell.com
The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic …

Evasion of neutralising antibodies by omicron sublineage BA. 2.75

DJ Sheward, C Kim, J Fischbach… - The Lancet Infectious …, 2022 - thelancet.com
Towards the end of 2021, SARS-CoV-2 vaccine effectiveness was threatened by the
emergence of the omicron clade (B. 1.1. 529), with more than 30 mutations in the spike …

Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

F Zuo, H Abolhassani, L Du, A Piralla… - Nature …, 2022 - nature.com
The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and
the urgent need to study more efficient vaccination strategies. Here we observed that an …

SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

J Pušnik, WO Monzon-Posadas, J Zorn… - Nature …, 2023 - nature.com
The elicited anti-SARS-CoV-2 immunity is becoming increasingly complex with individuals
receiving a different number of vaccine doses paired with or without recovery from …

Omicron sublineage BA. 2.75. 2 exhibits extensive escape from neutralising antibodies

DJ Sheward, C Kim, J Fischbach, K Sato… - The Lancet Infectious …, 2022 - thelancet.com
(A) Differences from BA. 2 in BA. 2.75 (orange), and BA. 2.75. 2 (red, underlined), depicted
upon the SARS-CoV-2 BA. 2 receptor binding domain (pdb: 7UB0). Sensitivity of SARS-CoV …