Calibration of ionic and cellular cardiac electrophysiology models
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …
mathematical models of biological systems. This maturity is bringing new challenges as …
A heart for diversity: simulating variability in cardiac arrhythmia research
In cardiac electrophysiology, there exist many sources of inter-and intra-personal variability.
These include variability in conditions and environment, and genotypic and molecular …
These include variability in conditions and environment, and genotypic and molecular …
Cell-specific cardiac electrophysiology models
W Groenendaal, FA Ortega… - PLoS computational …, 2015 - journals.plos.org
The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …
using data collected from many cells. Equations are derived for each relevant cellular …
High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment
The use of computational models to predict drug-induced changes in the action potential
(AP) is a promising approach to reduce drug safety attrition but requires a better …
(AP) is a promising approach to reduce drug safety attrition but requires a better …
hERG inhibitors with similar potency but different binding kinetics do not pose the same proarrhythmic risk: implications for drug safety assessment
Drug Mode of Action and hERG‐Related Safety Introduction Since the discovery of the link
that exists between drug‐induced hERG inhibition and Torsade de Pointes (TdP), extreme …
that exists between drug‐induced hERG inhibition and Torsade de Pointes (TdP), extreme …
[HTML][HTML] Model-driven optimal experimental design for calibrating cardiac electrophysiology models
Abstract Background and Objective: Models of the cardiomyocyte action potential have
contributed immensely to the understanding of heart function, pathophysiology, and the …
contributed immensely to the understanding of heart function, pathophysiology, and the …
Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms
T Krogh‐Madsen, EA Sobie… - The Journal of …, 2016 - Wiley Online Library
Mathematical models of cardiac electrophysiology are instrumental in determining
mechanisms of cardiac arrhythmias. However, the foundation of a realistic multiscale heart …
mechanisms of cardiac arrhythmias. However, the foundation of a realistic multiscale heart …
[HTML][HTML] Molecular determinants of pro-arrhythmia proclivity of d-and l-sotalol via a multi-scale modeling pipeline
KR DeMarco, PC Yang, V Singh, K Furutani… - Journal of molecular and …, 2021 - Elsevier
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug
sotalol, an antiarrhythmic drug comprising d-and l-enantiomers that both block the hERG …
sotalol, an antiarrhythmic drug comprising d-and l-enantiomers that both block the hERG …
Models of HERG gating
GCL Bett, Q Zhou, RL Rasmusson - Biophysical journal, 2011 - cell.com
Abstract HERG (Kv11. 1, KCNH2) is a voltage-gated potassium channel with unique gating
characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation …
characteristics. HERG has fast voltage-dependent inactivation, relatively slow deactivation …
Extracellular proton depression of peak and late Na+ current in the canine left ventricle
L Murphy, D Renodin, C Antzelevitch… - American Journal …, 2011 - journals.physiology.org
Cardiac ischemia reduces excitability in ventricular tissue. Acidosis (one component of
ischemia) affects a number of ion currents. We examined the effects of extracellular acidosis …
ischemia) affects a number of ion currents. We examined the effects of extracellular acidosis …