Immunotherapy has revolutionized the contemporary oncology landscape, with durable
responses possible across a range of cancer types. However, the majority of cancer patients …

The interest in bone marrow adiposity (BMA) has increased over the last decade due to its
association with, and potential role, in a range of diseases (osteoporosis, diabetes …

Biological tissues comprise a spatially complex structure, composition and organization at
the microscale, named the microstructure. Given the close structure-function relationships in …

Tissue engineering is a rapidly evolving, multidisciplinary field that aims at generating or
regenerating 3D functional tissues for in vitro disease modeling and drug screening …

Osteoarthritis causes debilitating pain and disability, resulting in a considerable
socioeconomic burden, yet no drugs are available that prevent disease onset or …

Detecting breast tissue alterations is essential for cancer diagnosis. However, inherent
bidimensionality limits histological procedures' effectiveness in identifying these changes …

Background Modern high-spatial-resolution radiologic methods enable increasingly detailed
volumetric postmortem investigations of human neuroanatomy for diagnostic, research, and …

Background The University of Southampton, in collaboration with the University Hospital
Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront …

To advance clinical translation of regenerative medicine, there is, amongst others, still need
for better insights in tissue development and disease. For this purpose, more precise …

Background Due to the lack of understanding of the fascicular organisation, vagus nerve
stimulation (VNS) leads to unwanted off-target effects. Micro-computed tomography …