The enteric nervous system (ENS) is sometimes called the “second brain” because of the
diversity of neuronal cell types and complex, integrated circuits that permit the ENS to …

Hirschsprung disease is a neurocristopathy, characterized by aganglionosis in the distal
bowel. It is caused by failure of the enteric nervous system progenitors to migrate, proliferate …

Background Transplanting autologous patient‐derived enteric neuronal stem/progenitor
cells (ENSC s) is an innovative approach to replacing missing enteric neurons in patients …

Background: Enteric neural stem/progenitor cells (ENSCs) offer an innovative approach to
treating Hirschsprung disease (HSCR) and other enteric neuropathies. However, postnatal …

Cell therapy is a promising approach to generate an enteric nervous system (ENS) and treat
enteric neuropathies. However, for translation to the clinic, it is highly likely that enteric …

Hirschsprung's disease (HSCR) is a developmental disorder of the enteric nervous system
(ENS) derived from neural crest cells (NCCs), which affects their migration, proliferation …

Hirschsprung's disease (HSCR) is characterized by a lack of enteric nervous system
ganglion cells (aganglionosis) in a variable extent of distal bowel. It is the most common …

Background Social media can be particularly useful for patients or families affected by rare
conditions by allowing individuals to form online communities across the world. Objective …

Hirschsprung's disease (HD) is a relatively common cause of intestinal obstruction in the
newborn. It is characterized by absence of ganglionic cells in the distal bowel beginning at …

Abstract Background/Purpose We have previously shown that embryonic enteric neural
stem cells (NSCs) isolated from the intestine colonize aganglionic intestine upon …