Predicting inhibitor potency is critical in drug design and development, yet it has remained
one of computational biology's biggest unresolved challenges. Here, we show that in the …

Acetylcholinesterase (AChE) is one of the classical targets in the treatment of Alzheimer's
disease (AD). Inhibition of AChE slows down the hydrolysis of acetycholine and increases …

In order for computer-aided drug design to fulfil its long held promise of delivering new
medicines faster and cheaper, extensive development and validation work must be done …

Hydrothermally-driven shape memory polymers (SMPs) have been extensively studied due
to their advantage of having multiple response capabilities. In these SMPs, bound water …

Many gaps in our understanding of Alzheimer's disease remain despite intense research
efforts. One such prominent gap is the mechanism of Tau condensation and fibrillization …

Modern virtual high-throughput screening (vHTS) pipelines tend to be overmarketed and
undervalidated, with no rigorous studies conclusively demonstrating that every one of their …

Choline-O-sulfatase (COSe; EC 3.1. 6.6) is a member of the alkaline phosphatase (AP)
superfamily, and its natural function is to hydrolyze choline-O-sulfate into choline and …

Alzheimer's Disease (AD) is a neurodegenerative disorder with severe consequences and
lethal outcome. One of the pathological hallmarks of the disease is the formation of insoluble …

Choline-O-sulfatase (COSe; EC 3.1. 6.6) is a member of the alkaline phosphatase (AP)
superfamily, and its natural function is to hydrolyze choline-O-sulfate into choline and …

Shape memory polymer (SMP)[1-4] is one type of smart materials which can respond to
specific environmental stimuli, retain a temporary shape, and then regain its initial shape …