Lipid nanoparticles: a novel gene delivery technique for clinical application
R Mashima, S Takada - Current Issues in Molecular Biology, 2022 - mdpi.com
Lipid nanoparticles (LNPs) are an emerging vehicle for gene delivery that accommodate
both nucleic acid and protein. Based on the experience of therapeutic liposomes, current …
both nucleic acid and protein. Based on the experience of therapeutic liposomes, current …
Induction of bleb structures in lipid nanoparticle formulations of mRNA leads to improved transfection potency
The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent
on the ionizable cationic lipid component. LNP mRNA systems composed of optimized …
on the ionizable cationic lipid component. LNP mRNA systems composed of optimized …
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing …
Introduction Polymer-lipid hybrid nanoparticle (PLN) is an emerging nanoplatform with
distinct properties and functionalities from other nanocarrier systems. PLN can be optimized …
distinct properties and functionalities from other nanocarrier systems. PLN can be optimized …
Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment …
To develop a combinatorial artificial-neural-network design-of-experiment (ANN-DOE)
model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate …
model, the effect of ionizable lipid, an ionizable lipid-to-cholesterol ratio, N/P ratio, flow rate …
A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles
Lipid nanoparticle (LNP) formulations are a proven method for the delivery of nucleic acids
for gene therapy as exemplified by the worldwide rollout of LNP-based RNAi therapeutics …
for gene therapy as exemplified by the worldwide rollout of LNP-based RNAi therapeutics …
Quantitative visualization of lipid nanoparticle fusion as a function of formulation and process parameters
Lipid nanoparticles (LNPs) have proven to be promising delivery vehicles for RNA-based
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …
vaccines and therapeutics, particularly in LNP formulations containing ionizable cationic …
Mammalian sulfatases: Biochemistry, disease manifestation, and therapy
R Mashima, M Nakanishi - International Journal of Molecular Sciences, 2022 - mdpi.com
Sulfatases are enzymes that catalyze the removal of sulfate from biological substances, an
essential process for the homeostasis of the body. They are commonly activated by the …
essential process for the homeostasis of the body. They are commonly activated by the …
RNA-Based Therapeutic Technology
R Mashima, S Takada, Y Miyamoto - International Journal of Molecular …, 2023 - mdpi.com
RNA-based therapy has been an expanding area of clinical research since the COVID-19
outbreak. Often, its comparison has been made to DNA-based gene therapy, such as adeno …
outbreak. Often, its comparison has been made to DNA-based gene therapy, such as adeno …
An Ultrahydrating Polymer that Protects Protein Therapeutics and RNA‐Lipid Nanoparticles Against Freezing, Heat and Lyophilization Stress
A Herrmann, S Abbina, NV Bathula… - Advanced Functional …, 2024 - Wiley Online Library
RNA and protein‐based therapeutics constitute almost half of recent drug approvals and
receive considerable attention within biotechnology industries. Ensuring their stability and …
receive considerable attention within biotechnology industries. Ensuring their stability and …
Determination of the interior pH of lipid nanoparticles using a pH-sensitive fluorescent dye-based DNA probe
Lipid nanoparticles (LNPs) containing ionizable cationic lipids are proven delivery systems
for therapeutic nucleic acids, such as small interfering RNA (siRNA). It is important to …
for therapeutic nucleic acids, such as small interfering RNA (siRNA). It is important to …