For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the
most deleterious types of DNA lesions. DSB processing and repair can cause sequence …

Chagas' disease is caused by the protozoan Trypanosoma cruzi, described in the early 20th
century by the Brazilian physician Dr. Carlos Chagas. There was a great amount of research …

Mitochondrial gene expression in Saccharomyces cerevisiae is responsible for the
production of highly hydrophobic subunits of the oxidative phosphorylation system …

CRISPR/Cas9 technology has revolutionized biology. This prokaryotic defense system
against foreign DNA has been repurposed for genome editing in a broad range of cell …

In recent years, eukaryotic microorganisms have been widely applied to offer many solutions
for everyday life and have come to play important roles in agriculture, food, health care, and …

Detection of genetic exchange has been a limiting factor to deepen the knowledge on the
mechanisms by which Trypanosoma cruzi is able to generate progeny and genetic diversity …

The co-synthesis of DNA and RNA potentially generates conflicts between replication and
transcription, which can lead to genomic instability. In trypanosomatids, eukaryotic parasites …

Like in most eukaryotes, the linear chromosomes of Trypanosoma cruzi end in a
nucleoprotein structure called the telomere, which is preceded by regions of variable length …

On 15 July 2020 was the 15th anniversary of the Science Magazine issue that reported three
trypanosomatid genomes, namely Leishmania major, Trypanosoma brucei, and …

In Trypanosoma cruzi, the etiologic agent of Chagas disease, Rad51 (TcRad51) is a central
enzyme for homologous recombination. Here we describe the different roles of TcRad51 in …