Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

Dietary iron assimilation is critical for health and essential to prevent iron-deficient states
and related comorbidities, such as anemia. The bioavailability of iron is generally low, while …

Abstract The SLC7A11/GPX4 axis plays an important role in ferroptosis during cardiac
ischemia/reperfusion injury (IRI). The present study was designed to evaluate the impact of …

Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed
to the accumulation of lipid hydroperoxides and redox imbalance. In recent years …

Abstract Four-octyl itaconate (4-OI) is the cell-permeable derivative of itaconate that can
activate Nrf2 signaling by alkylating Keap1's cysteine residues. Here, we tested the potential …

Iron is essential for energy metabolism, and states of iron deficiency or excess are
detrimental for organisms and cells. Therefore, iron and carbohydrate metabolism are tightly …

Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of
cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal …

Iron overload (IO) is associated with cardiovascular diseases, including heart failure. Our
study's aim was to examine the mechanism by which IO triggers cell death in H9c2 cells. IO …

Iron is the most abundant trace element in the human body. Since iron can switch between
its 2-valent and 3-valent form it is essential in various physiological processes such as …