The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

M Hostrup, J Onslev - The Journal of Physiology, 2022 - Wiley Online Library
Abstract Treatment of obesity with repurposed or novel drugs is an expanding research field.
One approach is to target beta2‐adrenergic receptors because they regulate the metabolism …

Formulation and therapeutic evaluation of isoxsuprine-loaded nanoparticles against diabetes-associated stroke

HA Abou-Taleb, BN Aldosari, RM Zaki, O Afzal… - Pharmaceutics, 2023 - mdpi.com
Ischemic stroke is the second-leading cause of death. Hyperglycemia, which is characteristic
of diabetes mellitus, contributes to the development of endothelial dysfunction and increases …

In vitro and in vivo evaluation of isoxsuprine loaded invasomes for efficient treatment of diabetes‐accelerated atherosclerosis

HA Abou-Taleb, RM Zaki, AA Hefny, O Afzal… - Journal of Drug Delivery …, 2024 - Elsevier
Hyperglycemia in diabetes mellitus exacerbates vascular disarray in atherosclerosis by
damaging endothelial cells and vascular smooth muscles. It's a major contributor to deaths …