Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

In recent years, a growing consensus is emerging that the mechanical microenvironment of
tumors is far more critical in the onset of tumor, tumor progression, invasion, and metastasis …

Biophysical cues of rigid tumor matrix play a critical role in cancer cell malignancy. We report
that stiffly confined cancer cells exhibit robust growth of spheroids in the stiff hydrogel that …

There is a consensus about the strong correlation between the elasticity of cells and tissue
and their normal, dysplastic, and cancerous states. However, developments in cell …

Colorectal cancer (CRC) progression is a complex process that is not well understood. We
describe an in vitro organ-on-chip model that emulates in vivo tissue structure and the tumor …

Intestinal stem cells (ISC) are crucial players in colon epithelium physiology. The accurate
control of their auto-renewal, proliferation and differentiation capacities provides a constant …

Eph receptors constitute the largest family of receptor tyrosine kinases, which are activated
by ephrin ligands that either are anchored to the membrane or contain a transmembrane …

Abstract Background Interleukin-11 (IL-11), a dominant IL-6 family cytokine, is involved in
tumorigenesis, tumor progression and differentiation in colon cancer cells. IL-11 signaling …

The aim of this study is to explore the differentially expressed lncRNAs, which may have
potential biological function and diagnostic value in colorectal cancer (CRC). Through …

Atomic Force Microscopy (AFM) has the unique capability of probing the nanoscale
mechanical properties of biological systems that affect and are affected by the occurrence of …