The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

The complexity of the pathogenetic mechanisms of the development of chronic inflammation
in asthma determines its heterogeneity and insufficient treatment effectiveness. Nuclear …

Inflammatory response plays an essential role in the resolution of infections. However,
inflammation can be detrimental to an organism and cause irreparable damage. For …

Abstract Titanium dioxide nanoparticles (TiO 2 NPs) are revolutionizing biomedicine due to
their potential application as diagnostic and therapeutic agents. However, the TiO 2 NP …

MARCKS (myristoylated alanine-rich C-kinase substrate) is a membrane-associated protein
expressed in many cell types, including macrophages. MARCKS is functionally implicated in …

With the success of the Human Genome Project, large-scale systemic projects became a
reality that enabled rapid development of the systems biology field. Systems biology …

Mass-spectrometry (MS)-based proteomics is a powerful and robust platform for studying the
interactions between biological systems during health and disease. Bacterial infections …

In patients with active lupus, spontaneous endotoxemia and possibly tolerance to
lipopolysaccharide (LPS) is a potentially adverse complication. Similarly, previous reports …

Pseudomonas aeruginosa is the most common human opportunistic pathogen associated
with nosocomial diseases. In 2017, the World Health Organization has classified P …

The innate immune system is the body's first line of defense against pathogens and its
protection against infectious diseases. On the surface of host myeloid cells, Toll-like receptor …