NAXE deficiency: A neurometabolic disorder of NAD (P) HX repair amenable for metabolic correction
Abstract The NAD (P) HX repair system is a metabolite damage repair mechanism
responsible for restoration of NADH and NADPH after their inactivation by hydration …
responsible for restoration of NADH and NADPH after their inactivation by hydration …
[HTML][HTML] Metabolomic, lipidomic and proteomic characterisation of lipopolysaccharide-induced inflammation mouse model
E Puris, Š Kouřil, L Najdekr, S Auriola, S Loppi… - Neuroscience, 2022 - Elsevier
Neuroinflammation is an important feature in the pathogenesis and progression of central
nervous system (CNS) diseases including Alzheimer's disease (AD). One of the widely used …
nervous system (CNS) diseases including Alzheimer's disease (AD). One of the widely used …
Protein expression of amino acid transporters is altered in isolated cerebral microvessels of 5xFAD mouse model of Alzheimer's disease
E Puris, L Saveleva, I de Sousa Maciel… - Molecular …, 2023 - Springer
Membrane transporters such as ATP-binding cassette (ABC) and solute carrier (SLC)
transporters expressed at the neurovascular unit (NVU) play an important role in drug …
transporters expressed at the neurovascular unit (NVU) play an important role in drug …
Early-life stress and dietary fatty acids impact the brain lipid/oxylipin profile into adulthood, basally and in response to LPS
K Reemst, JY Broos, MR Abbink, C Cimetti… - Frontiers in …, 2022 - frontiersin.org
Brain lipid dysregulation is a hallmark of depression and Alzheimer's disease, also marked
by chronic inflammation. Early-life stress (ELS) and dietary intake of polyunsaturated fatty …
by chronic inflammation. Early-life stress (ELS) and dietary intake of polyunsaturated fatty …
Systemic inflammation induced changes in protein expression of ABC transporters and ionotropic glutamate receptor subunit 1 in the cerebral cortex of familial …
E Puris, S Auriola, P Korhonen, S Loppi… - Journal of …, 2021 - Elsevier
Alzheimer's disease (AD) is an incurable disease, with complex pathophysiology and a
myriad of proteins involved in its development. In this study, we applied quantitative targeted …
myriad of proteins involved in its development. In this study, we applied quantitative targeted …
Increased expression and activity of brain cortical cPLA2 due to chronic lipopolysaccharide administration in mouse model of familial Alzheimer's disease
M Gynther, ML Estrada, S Loppi, P Korhonen… - Pharmaceutics, 2022 - mdpi.com
Cytosolic phospholipase A2 (cPLA2) is an enzyme regulating membrane phospholipid
homeostasis and the release of arachidonic acid utilized in inflammatory responses. It …
homeostasis and the release of arachidonic acid utilized in inflammatory responses. It …
牙周致病菌与阿尔茨海默病相关性研究进展
唐沛妍 - 中国微生态学杂志, 2021 - cjm.dmu.edu.cn
阿尔茨海默病(Alzheimer′ s disease, AD) 是一种进行性神经退行性疾病,
其主要致病机制目前尚不清楚, 临床上也缺乏有效的药物缓解病程的发生和发展 …
其主要致病机制目前尚不清楚, 临床上也缺乏有效的药物缓解病程的发生和发展 …
[HTML][HTML] Systemic inflammation elevates cytosolic prolyl oligopeptidase protein expression but not peptidase activity in the cerebral cortices of familial Alzheimers …
E Puris, A Jalkanen, S Auriola, S Loppi, P Korhonen… - Brain Disorders, 2022 - Elsevier
Abstract Changes in brain prolyl oligopeptidase (PREP) expression and activity have been
associated with neuroinflammation and Alzheimers disease (AD). The role of PREP in AD …
associated with neuroinflammation and Alzheimers disease (AD). The role of PREP in AD …
[图书][B] Gut Microbial and Metabolic Contributions to Preclinical Alzheimer's Disease
MB Heston - 2023 - search.proquest.com
Alzheimer's disease (AD) is the most common dementia worldwide and the 7 th leading
cause of death in the United States, projected to incur a healthcare burden of $1 trillion in …
cause of death in the United States, projected to incur a healthcare burden of $1 trillion in …
[PDF][PDF] Broos,.., bbink
K Reemst - MR, Cimetti, C., Giera, M., Kooi, G., & …, 2022 - scholarlypublications …
There is increasing evidence that lipid dysregulation in the brain might represent a key event
in the pathophysiology of neurological diseases such as depression and Alzheimer's …
in the pathophysiology of neurological diseases such as depression and Alzheimer's …