Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
Gastric cancer is a major source of global cancer mortality with limited treatment options and
poor patient survival. As our molecular understanding of gastric cancer improves, we are …

Predictive biomarkers in gastric cancer

C Röcken - Journal of cancer research and clinical oncology, 2023 - Springer
Predictive biomarkers are the mainstay of precision medicine. This review summarizes the
advancements in tissue-based diagnostic biomarkers for gastric cancer, which is considered …

Estimating the Global Burden of Epstein-Barr Virus–Associated Gastric Cancer: A Systematic Review and Meta-Analysis

M Hirabayashi, D Georges, GM Clifford… - Clinical Gastroenterology …, 2023 - Elsevier
Background & Aims Evidence suggests that a fraction of new gastric cancer cases may be
etiologically associated with Epstein-Barr virus (EBV), a known carcinogenic agent. We …

Molecular classification of gastric cancer

C Röcken - Expert review of molecular diagnostics, 2017 - Taylor & Francis
Introduction: Gastric cancer is among the most common cancers worldwide. Despite
declining incidences, the prognosis remains dismal in Western countries and is better in …

Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges

J Garcia‐Pelaez, R Barbosa‐Matos, I Gullo… - Molecular …, 2021 - Wiley Online Library
Gastric cancer (GC) pathogenesis is complex and heterogeneous, reflecting morphological,
molecular and genetic diversity. Diffuse gastric cancer (DGC) and intestinal gastric cancer …

[HTML][HTML] Epstein-Barr virus and mismatch repair deficiency status differ between oesophageal and gastric cancer: A large multi-centre study

LC Hewitt, IZ Inam, Y Saito, T Yoshikawa… - European journal of …, 2018 - Elsevier
Abstract Background Oesophageal (OeC) and gastric (GC) cancer patients are treated with
similar multimodal therapy and have poor survival. There remains an urgent clinical need to …

Non-Helicobacter pylori Helicobacter (NHPH) positive gastric cancer

T Yasuda, HS Lee, SY Nam, H Katoh, Y Ishibashi… - Scientific Reports, 2022 - nature.com
Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter
(NHPH) are progressing. NHPH is reported to accompany nodular gastritis, gastric MALT …

[HTML][HTML] Chromosomal instability in gastric cancer biology

SS Maleki, C Röcken - Neoplasia, 2017 - Elsevier
Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the
total cancer incidence. The prognosis of GC is dismal in Western countries due to late …

Global updates in the treatment of gastric cancer: a systematic review. Part 1: staging, classification and surgical treatment

A Agnes, A Biondi, A Laurino, R Persiani, D D'Ugo - Updates in Surgery, 2020 - Springer
Gastric cancer (GC) is the fifth malignancy and the third cause of cancer death worldwide,
according to the global cancer statistics presented in 2018. Its definition and staging have …

Exploring the molecular characteristics of the malignant potential of gastric adenocarcinoma with enteroblastic differentiation

Y Wang, X Wei, B Ke, J Liu, Y Guo, Y Liu… - …, 2023 - Wiley Online Library
Aims Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subset of
alpha‐fetoprotein (AFP)‐producing carcinomas with poor prognosis. However, the …