Acetals and ketals and their nitrogen and sulfur homologues are often considered to be
unconventional and potentially problematic scaffolding elements or pharmacophores for the …

Over the past 20 years, the field of foldamers has rapidly increased. Many β-peptides have
already been described and shown interesting properties. γ-Peptides have more recently …

Exploitation of the biologic activity of neurotrophins is desirable for medical purposes, but
their protein nature intrinsically bears adverse pharmacokinetic properties. Here, we report …

Over the years biomedical research has been constantly oriented towards the development
of new therapeutics based on bioactive peptides and their analogues. In particular, the …

Natural products (NPs) have been shown to be an extraordinary source of bioactive
compounds and three-dimensional complex frameworks that can be useful to produce high …

Diversity-Oriented Synthesis (DOS) consists of generating structurally diverse compounds
from a complexity-generating reaction followed by cyclization steps and appendage …

Chemical genetics is an approach for identifying small molecules with the ability to induce a
biological phenotype or to interact with a particular gene product, and it is an emerging tool …

An efficient, multigram synthesis of a spiroisoxazolinoproline-based amino acid, 7, requiring
minimal purification, delivering good cis: trans diastereoselectivity (∼ 1: 4), and providing …

Two c [RGDfX] cyclopeptides, having either l-or d-morpholine-3-COOH (Mor) as the X amino
acid were developed as ligands for αvβ3/αvβ5 integrins. Biological assays showed only d …

Although known for their inferiority as hydrogen-bonding acceptors when compared to
amides, esters are often found at the C-terminus of peptides and synthetic oligomers …