It is assumed that the primary mode of action of 5-fluorouracil (5-FUra) is mediated via
inhibition of thymidylate synthetase. Persistent inhibition of cellular proliferation after …

The halogenated pyrimidines were synthesized in the 1950s as potential anti-tumor agents
after the discovery that certain tumors preferentially incorporated uracil rather than thymine …

We demonstrate a highly significant relationship (p less than 0.0001) between the
incorporation of 5-flourouracil in total cellular RNA and loss of clonogenic survival of the …

We have demonstrated previously the presence of 5-fluorouracil (FUra) residues in L1210
DNA. These findings have been extended to the MCF-7 human breast carcinoma cell line …

After more than three decades since their introduction, fluoropyrimidines, especially FUra,
are still a mainstay in the treatment of various solid malignancies. The antitumor effects of …

We are interested in determining whether incorporation of the drug 5-fluorouracil into pre-
mRNA can alter RNA processing. The effect of 5-fluorouracil (FUra) substitution on the in …

We have employed cesium sulfate density gradient centrifugation to separate RNA and DNA
of L1210 cells labeled with [3H] fluorodeoxyuridine. We have analyzed nucleotide and …

Addition of 5FU to the culture medium of mouse L-1210 cells resulted in inhibition of the
maturation process of ribosomal RNA precursors in vitro. In the presence of 10-6 M 5FU for 2 …

We have evaluated the RNA-directed cytotoxicity of 5-fluorouracil (5-FU) in human colonic
carcinoma cells. The mode of action of 5-FU and its effects on human pre-rRNA processing …

FUra is one of those few anticancer agents which was synthesized based on a logical
rationale (Heidelberger, 1965). It is an anticancer agent in use both alone and as a …