Renin-angiotensin system: The underlying mechanisms and promising therapeutical target for depression and anxiety

S Gong, F Deng - Frontiers in Immunology, 2023 - frontiersin.org
Emotional disorders, including depression and anxiety, contribute considerably to morbidity
across the world. Depression is a serious condition and is projected to be the top contributor …

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

I De Rojas, S Moreno-Grau, N Tesi… - Nature …, 2021 - nature.com
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and
together with polygenetic risk stratification can contribute towards planning of feasible and …

Lifespan intellectual factors, genetic susceptibility, and cognitive phenotypes in aging: implications for interventions

Y Wang, Y Du, J Li, C Qiu - Frontiers in Aging Neuroscience, 2019 - frontiersin.org
Along with rapid global population aging, the age-related cognitive disorders such as mild
cognitive impairment (MCI) and dementia have posed a serious threat to public health …

[HTML][HTML] Potentiation of NMDA Receptors by AT1 Angiotensin Receptor Activation in Layer V Pyramidal Neurons of the Rat Prefrontal Cortex

A Hanuska, P Ribiczey, E Kató, ZT Papp… - International Journal of …, 2024 - mdpi.com
NMDA receptors in the prefrontal cortex (PFC) play a crucial role in cognitive functions.
Previous research has indicated that angiotensin II (Ang II) affects learning and memory …

Atrial fibrillation increases the risk of dementia amongst older adults even in the absence of stroke

L Rydén, A Zettergren, NM Seidu, X Guo… - Journal of internal …, 2019 - Wiley Online Library
Background Atrial fibrillation increases risk of stroke, and thus risk of cognitive impairment
and dementia. Emerging evidence suggests an association also in the absence of stroke …

Exploration of multifaceted molecular mechanism of angiotensin-converting enzyme 2 (ACE2) in pathogenesis of various diseases

AD Kunvariya, SA Dave, ZJ Modi, PK Patel, SR Sagar - Heliyon, 2023 - cell.com
Abstract Angiotensin converting enzyme 2 (ACE2) is a homolog of ACE (a transmembrane
bound dipeptidyl peptidase enzyme). ACE2 converts angiotensinogen to the heptapeptide …

Effectiveness of light therapy in cognitively impaired persons: a metaanalysis of randomized controlled trials

HL Chiu, PT Chan, H Chu, STS Hsiao… - Journal of the …, 2017 - Wiley Online Library
Objectives To explore the effects of light therapy on behavioral disturbances (BD s), sleep
quality, and depression. Design Meta‐analysis of randomized controlled trials. Setting …

[PDF][PDF] 成功认知老化的研究综述

林岚, 金悦, 吴水才 - 中国医疗设备, 2022 - cs.china-cmd.org
人口老龄化的快速发展使得成功认知老化在基础科学和公共卫生的研究工作中越来越受关注.
本文对成功认知老化的相关研究进行了综述, 首先概述了成功认知老化的定义与划分 …

Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression

DC Steffens, ME Garrett, KL Soldano… - International …, 2024 - cambridge.org
Objective: This study sought to conduct a comprehensive search for genetic risk of cognitive
decline in the context of geriatric depression. Design: A genome-wide association study …

Arterial blood pressure variability and other vascular factors contribution to the cognitive decline in Parkinson's disease

A Pierzchlińska, M Kwaśniak-Butowska, J Sławek… - Molecules, 2021 - mdpi.com
Dementia is one of the most disabling non-motor symptoms in Parkinson's disease (PD).
Unlike in Alzheimer's disease, the vascular pathology in PD is less documented. Due to the …