The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …

Darifenacin hydrobromide is a selective muscarinic M 3 receptor antagonist that is indicated
for use in treatment of overactive bladder disorder. Darifenacin was found to have a short …

Characterization of the circulating metabolites for a new chemical entity in humans is
essential for safety assessment, an understanding of their contributions to pharmacologic …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The contribution of (S)‐warfarin to the
clinical effect of rac‐warfarin is well understood. The extent to which (R)‐warfarin contributes …

ABSTRACT A population pharmacokinetics analysis was performed after intravenous
ganciclovir and oral valganciclovir in solid organ transplant patients with cytomegalovirus …

Antagonists of muscarinic acetylcholine receptors, such as darifenacin, oxybutynin,
propiverine, solifenacin, tolterodine, and trospium, are the mainstay of the treatment of the …

This chapter introduces the theory behind nonlinear mixed effects models through the
concept of a structural model or covariate model coupled to both fixed and random effects in …

Background and purpose: Tesofensine is a centrally acting drug under clinical development
for Alzheimer's disease, Parkinson's disease and obesity. In vitro, the major metabolite of …

Benign hyperplasia (BHP) is a common disorder that affects men over the age of 60 years.
Transurethral resection of the prostate (TURP) is the gold standard for operative treatment …

Objectives Extensive but fragmented data from existing studies were used to describe the
drug–drug interaction between rifabutin and HIV PIs and predict doses achieving …