Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Acetylation of the ϵ‐amino group of lysine residues, or Nϵ‐lysine acetylation, is an
important post‐translational modification known to occur in histones, transcription factors …

In response to DNA damage, the activity of the p53 tumor suppressor is modulated by
protein stabilization and post-translational modifications including acetylation. Interestingly …

Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the
proapoptotic factor Bax. The Ku70 DNA end-joining protein has recently been shown to …

p53 promotes tumor suppression through its ability to function as a transcriptional factor and
is activated by posttranslational modifications that include acetylation. Our earlier study …

Adenovirus continues to be an important model system for investigating basic aspects of cell
biology. Interactions of several cellular proteins with E1A conserved regions (CR) 1 and 2 …

The c-MYC oncoprotein functions as a sequence-specific transcription factor. The ability of c-
MYC to activate transcription relies in part on the recruitment of cofactor complexes …

During the early phase of infection, the E1B-55K protein of adenovirus type 5 (Ad5) counters
the E1A-induced stabilization of p53, whereas in the late phase, E1B-55K modulates the …

Histone acetylation plays an important role in regulating the chromatin structure and is tightly
regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone …

Chromatin remodeling and activation of transcription are important aspects of gene
regulation, but these often go awry in disease progression, including during colon cancer …