Elucidating the prefrontal cortical microcircuit has been challenging, given its role in multiple
complex behaviors, including working memory, cognitive flexibility, attention, social …

Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

Persistent and ramping neural activity in the frontal cortex anticipates specific movements,,,,–
. Preparatory activity is distributed across several brain regions,, but it is unclear which brain …

While the interaction of the cardinal rhythms of non-rapid-eye-movement (NREM) sleep—the
thalamo-cortical spindles, hippocampal ripples, and the cortical slow oscillations—is thought …

Vagus nerve stimulation (VNS) is a neuromodulation therapy for a broad and expanding set
of neurologic conditions. However, the mechanism through which VNS influences central …

Persistent neural activity maintains information that connects past and future events. Models
of persistent activity often invoke reverberations within local cortical circuits, but long-range …

Short-term memories link events separated in time, such as past sensation and future
actions. Short-term memories are correlated with slow neural dynamics, including selective …

An increasingly powerful approach for studying brain circuits relies on targeting genetically
encoded sensors and effectors to specific cell types. However, current approaches for this …

Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition.
However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we …

How the brain selects appropriate sensory inputs and suppresses distractors is unknown.
Given the well-established role of the prefrontal cortex (PFC) in executive function, its …