Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the
experienced intensivist as a “complicated clinical course” and is frequently attributed to …

Sepsis, a common and potentially fatal systemic illness, is triggered by microbial infection
and often leads to impaired function of the lungs, kidneys or other vital organs. Since the …

Although several dozen studies of gene expression in sepsis have been published,
distinguishing sepsis from a sterile systemic inflammatory response syndrome (SIRS) is still …

Rationale: Using microarray data, we previously identified gene expression–based
subclasses of septic shock with important phenotypic differences. The subclass-defining …

Dysregulated host responses to infection can lead to organ dysfunction and sepsis, causing
millions of global deaths each year. To alleviate this burden, improved prognostication and …

BACKGROUND We recently proffered that a new syndrome persistent inflammation,
immunosuppression, and catabolism syndrome (PICS) has replaced late multiple-organ …

Glucocorticoids have strong regulatory actions on the immune system and act as potent
therapeutic compounds for autoimmune and inflammatory diseases. We previously reported …

BACKGROUND The epidemiology of multiple-organ failure (MOF) after injury has been
changing, questioning the validity of previously described prediction models. This study …

Objective: In response to a need for better sepsis diagnostics, several new gene expression
classifiers have been recently published, including the 11-gene “Sepsis MetaScore,” the …

There is currently no reliable tool available to measure immune dysfunction in septic
patients in the clinical setting. This proof-of-concept study assesses the potential of gene …