Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers
Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell …
Whole-genome sequencing reveals the genetic mechanisms of domestication in classical inbred mice
Background The laboratory mouse was domesticated from the wild house mouse.
Understanding the genetics underlying domestication in laboratory mice, especially in the …
Understanding the genetics underlying domestication in laboratory mice, especially in the …
[HTML][HTML] Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review
A Moore, MD Ritchie - Genes, 2024 - mdpi.com
Background/Objectives: Cardiovascular disease (CVD) and Alzheimer's disease (AD) are
two diseases highly prevalent in the aging population and often co-occur. The exact …
two diseases highly prevalent in the aging population and often co-occur. The exact …
β-Asarone attenuates aβ-induced neuronal damage in PC12 cells overexpressing APPswe by restoring autophagic flux
Z Li, J Ma, Z Kuang, Y Jiang - Frontiers in Pharmacology, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory damage and cognitive dysfunction. Studies have shown that defective autophagic …
memory damage and cognitive dysfunction. Studies have shown that defective autophagic …
Familial Alzheimer's disease and recessive modifiers
Alzheimer's disease (AD) is progressive brain disorder that affects~ 50 million people
worldwide and has no current effective treatment. AD age of onset (ADAOO) has shown to …
worldwide and has no current effective treatment. AD age of onset (ADAOO) has shown to …
A comprehensive machine learning framework for the exact prediction of the age of onset in familial and sporadic Alzheimer's disease
JI Vélez, LA Samper, M Arcos-Holzinger, LG Espinosa… - Diagnostics, 2021 - mdpi.com
Machine learning (ML) algorithms are widely used to develop predictive frameworks.
Accurate prediction of Alzheimer's disease (AD) age of onset (ADAOO) is crucial to …
Accurate prediction of Alzheimer's disease (AD) age of onset (ADAOO) is crucial to …
Effects of rs958804 and rs7858836 single‐nucleotide polymorphisms of the ASTN2 gene on pain‐related phenotypes in patients who underwent laparoscopic …
R Inoue, D Nishizawa, J Hasegawa… - …, 2021 - Wiley Online Library
Background Opioids are widely used as effective analgesics, but opioid sensitivity varies
widely among individuals. The underlying genetic and nongenetic factors are not fully …
widely among individuals. The underlying genetic and nongenetic factors are not fully …
[图书][B] Genetic Characterization of Neurodegenerative Diseases: From an Understudied Population to a National Biobank
N Dehghani - 2023 - search.proquest.com
Neurodegenerative diseases, such as Alzheimer's disease, result in severe cognitive
decline and memory impairment, which negatively affects both patient and caregiver quality …
decline and memory impairment, which negatively affects both patient and caregiver quality …
Acupuncture and Alzheimer's Disease
Y Xu, G Wen, T Asakawa, Y Xia - Advanced Acupuncture Research: From …, 2022 - Springer
Alzheimer's disease (AD) is the main cause of dementia and one of the most common kinds
of neurodegenerative diseases. However, its etiology and pathophysiology remain unclear …
of neurodegenerative diseases. However, its etiology and pathophysiology remain unclear …
The Role of Gremlin2 in Hippocampal Neurogenesis and Neurological Disorders
N Frazer - 2023 - search.proquest.com
Abstract The Bone Morphogenic Protein (BMP) signaling pathway is vital in neural
progenitor cell proliferation, specification, and differentiation. The BMP signaling antagonist …
progenitor cell proliferation, specification, and differentiation. The BMP signaling antagonist …