Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …

A DNA triplex is formed when pyrimidine or purine bases occupy the major groove of the
DNA double Helix forming Hoogsteen pairs with purines of the Watson-Crick basepairs …

R-loops are ubiquitous, dynamic nucleic-acid structures that play fundamental roles in DNA
replication and repair, chromatin and transcription regulation, as well as telomere …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

Repetitive DNA motifs are abundant in the genomes of various species and have the
capacity to adopt non-canonical (ie, non-B) DNA structures. Several non-B DNA structures …

Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Nucleic acids can be selectively recognized by a large number of natural and synthetic
ligands. Oligonucleotides provide the highest specificity of recognition. They can bind to a …

DNA structure is a critical element in determining its function. The DNA molecule is capable
of adopting a variety of non-canonical structures, including three-stranded (ie triplex) …

Repetitive genomic sequences can adopt a number of alternative DNA structures that differ
from the canonical B-form duplex (ie non-B DNA). These non-B DNA-forming sequences …