The precise patterns of neuronal assembly during development determine all functional
outputs of a nervous system; these may range from simple reflexes to learning, memory …

Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

With human median lifespan extending into the 80s in many developed countries, the
societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes …

The neuromuscular junction (NMJ) plays a fundamental role in transferring information from
lower motor neuron to skeletal muscle to generate movement. It is also an experimentally …

The absence of dystrophin in Duchenne muscular dystrophy disrupts the dystrophin-
associated glycoprotein complex resulting in skeletal muscle fiber fragility and atrophy …

Abstract An implanted neurotrophin-3 (NT3)-chitosan scaffold can recruit endogenous
neural stem cells to migrate to a lesion region and differentiate into mature neurons after …

Recently, we provided genetic basis showing that mitochondrial dysfunction can trigger
motor neuron degeneration, through identification of CHCHD10 encoding a mitochondrial …

Botulinum toxin-A (BTX) administration into muscle is an established treatment for conditions
with excessive muscle contraction. However, botulinum therapy has short-term …

The neuromuscular junction (NMJ)—a synapse formed between lower motor neuron and
skeletal muscle fibre—represents a major focus of both basic neuroscience research and …

Microtubules (MTs) are known to be post-translationally modified at the neuromuscular
junction (NMJ), hence increasing their stability. To date however, the function (s) of the …