The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

H Beraldo, D Gambino - Mini reviews in medicinal chemistry, 2004 - europepmc.org
The more significant bioactivities of a variety of semicarbazones (anti-protozoa,
anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and …

Main group metal complexes of semicarbazones and thiosemicarbazones. A structural review

JS Casas, MS Garcıa-Tasende, J Sordo - Coordination Chemistry Reviews, 2000 - Elsevier
The structural aspects of the complexes formed by thiosemicarbazones (TSCs) and
semicarbazones (SCs) with the metallic elements of Groups 12, 13, 14 and 15 are surveyed …

Novel Tetranuclear Orthometalated Complexes of Pd(II) and Pt(II) Derived from p-Isopropylbenzaldehyde Thiosemicarbazone with Cytotoxic Activity in cis-DDP …

AG Quiroga, JM Pérez, I López-Solera… - Journal of Medicinal …, 1998 - ACS Publications
The reaction of p-isopropylbenzaldehyde thiosemicarbazone [p-is. TSCN], 1, with palladium
(II) acetate and potassium tetrachloroplatinate yielded two tetrameric orthopalladated …

Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: Synthesis, structure, spectroscopy, and biological activity

Z Afrasiabi, EKK Sinn, W Lin, Y Ma, C Campana… - Journal of Inorganic …, 2005 - Elsevier
Ni (II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were
synthesized and spectroscopically characterized. The X-ray crystal structure of both the …

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer

JA Ludwig, G Szakács, SE Martin, BF Chu, C Cardarelli… - Cancer research, 2006 - AACR
ATP-binding cassette (ABC) proteins include the best known mediators of resistance to
anticancer drugs. In particular, ABCB1 [MDR1/P-glycoprotein (P-gp)] extrudes many types of …

Synthesis and characterization of novel palladium (II) complexes of bis (thiosemicarbazone). Structure, cytotoxic activity and DNA binding of Pd (II)-benzyl bis …

AI Matesanz, JM Pérez, P Navarro, JM Moreno… - Journal of inorganic …, 1999 - Elsevier
The preparation of palladium (II) complexes of 3, 5-diacyl-1, 2, 4-triazole bis
(thiosemicarbazone)(H2L2), 2, 6-diacylpyridine bis (thiosemicarbazone)(H2L3) and benzyl …

Electrochemical properties of some transition metal complexes: synthesis, characterization and in-vitro antimicrobial studies of Co (II), Ni (II), Cu (II), Mn (II) and Fe (III) …

AD Kulkarni, SA Patil, PS Badami - International Journal of Electrochemical …, 2009 - Elsevier
A series of first complexes of Co (II), Ni (II), Cu (II), Mn (II) and Fe (III) have been synthesized
with Schiff base derived from isatin monohydrazone and fluvastatin. The complexes have …

[HTML][HTML] Thiosemicarbazone derivatives of transition metals as multi-target drugs: a review

S Gupta, N Singh, T Khan, S Joshi - Results in Chemistry, 2022 - Elsevier
The mutations of bacteria and viruses along with the resistance of various targets to the
existing drugs have emerged as great challenges in the medical field. This imposes the …

Evaluation of the semicarbazones, thiosemicarbazones and bis-carbohydrazones of some aryl alicycylic ketones for anticonvulsant and other biological propertie

JR Dimmock, SN Pandeya, JW Quail… - European journal of …, 1995 - Elsevier
A number of aryl alicyclic ketones were converted to their corresponding semicarbazones,
thiosemicarbazones and bis-carbohydrazones. Anticonvulsant activity was displayed by …

Discovery of N-(2,6-Dimethylphenyl)-Substituted Semicarbazones as Anticonvulsants: Hybrid Pharmacophore-Based Design

P Yogeeswari, D Sriram, R Thirumurugan… - Journal of medicinal …, 2005 - ACS Publications
Epilepsy is the most common primary neurological disorder known. In the past decade,
various aryl semicarbazones have been designed that were structurally dissimilar from …