Cancer is widely perceived as a heterogeneous group of disorders with markedly different
biological properties, which are caused by a series of clonally selected genetic changes in …

As p53 and its homologue p73 have significant sequence and functional similarities, p73
might also be expected to act as a tumour suppressor. However, p73 is activated after DNA …

The tumor suppressor p53 is critically important in the cellular damage response and is the
founding member of a family of proteins. All three genes regulate cell cycle and apoptosis …

Cancer is as much an epigenetic disease as it is a genetic disease, and epigenetic
alterations in cancer often serve as potent surrogates for genetic mutations. Normal …

Introduction p53 continues to be one of the most intensively studied genes in cancer biology.
p53 was initially identified 20 years ago as a binding partner for the SV40 T oncoprotein …

Methylation associated inactivation of RASSF1, a putative tumor suppressor identified at
3p21. 3, has been frequently observed in several human malignancies, including lung and …

Molecular links between apoptosis, tumorigenesis and drug resistance provide starting
points for new therapeutic approaches and for a targeted cancer therapy. The discovery of …

TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein
isoforms through multiple mechanisms including extensive alternative mRNA splicing …

Gastric cancer is one of the most common malignancies worldwide and it is a fourth leading
cause of cancer-related death. Carcinogenesis is a multistage disease process specified by …

Simple Summary The p53 family is a complex family of transcription factors with different
cellular functions that are involved in several physiological processes. A massive amount of …