Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Rethinking antiphospholipid syndrome to guide future management and research

JS Knight, D Erkan - Nature Reviews Rheumatology, 2024 - nature.com
Antiphospholipid syndrome (APS) consists of thrombotic, non-thrombotic and obstetric
clinical manifestations developing in individuals with persistent antiphospholipid antibodies …

The role of neutrophil extracellular traps (NETs) in the pathogenesis of systemic lupus erythematosus and antiphospholipid syndrome

T Reshetnyak, K Nurbaeva - International Journal of Molecular Sciences, 2023 - mdpi.com
Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are two related
autoimmune diseases. In recent years, there has been sufficient evidence to suggest that …

Antiphospholipid syndrome pathogenesis in 2023: an update of new mechanisms or just a reconsideration of the old ones?

E Raschi, MO Borghi, F Tedesco, PL Meroni - Rheumatology, 2024 - academic.oup.com
Antibodies against phospholipid (aPL)-binding proteins, in particular, beta 2 glycoprotein I
(β2GPI), are diagnostic/classification and pathogenic antibodies in antiphospholipid …

The Role of the Oxidative State and Innate Immunity Mediated by TLR7 and TLR9 in Lupus Nephritis

R Echavarria, EG Cardona-Muñoz… - International Journal of …, 2023 - mdpi.com
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) and is
considered one of the leading causes of mortality. Multiple immunological pathways are …

Anti-phospholipid autoantibodies in human diseases

R Qin, H Wu, H Guan, C Tang, Z Zheng, C Deng… - Clinical …, 2023 - Elsevier
Anti-phospholipid autoantibodies are a group of antibodies that can specifically bind to
anionic phospholipids and phospholipid protein complexes. Recent studies have reported …

Inhalable DNase I@ Au hybrid nanoparticles for radiation sensitization and metastasis inhibition by elimination of neutrophil extracellular traps

Y Sun, J He, W Chen, Y Wang, K Wang, M Zhou… - Biomaterials, 2025 - Elsevier
High-dose radiation therapy is a widely used clinical strategy to inhibit tumor growth.
However, the rapid generation of excessive reactive oxygen species (ROS) triggers the …

Antibodies to Neutrophil Extracellular Traps: Novel Markers for the Antiphospholipid Syndrome.

DS Pisetsky - Arthritis & Rheumatology, 2023 - search.ebscohost.com
The article presents a study by Zuo et al that examines autoantibody expression in patients
with antiphospholipid antibodies (aPL), particularly those with antiphospholipid syndrome …

Anticoagulant and non-anticoagulant therapy in thrombotic antiphospholipid syndrome: old drugs and new treatment targets

G Ruiz-Irastorza, MG Tektonidou… - Rheumatology, 2024 - academic.oup.com
In this review, we discuss the current evidence on classic and newer oral anticoagulant
therapy, older drugs such as HCQ and statins, and new potential treatment targets in APS …

The role of neutrophil extracellular traps in inflammatory rheumatic diseases

N Hanata, MJ Kaplan - Current Opinion in Rheumatology, 2025 - journals.lww.com
Growing evidence has suggested the contribution of NET dysregulation to the pathogenesis
of several inflammatory rheumatic diseases. Further research is warranted in regard to …