Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Epigenetics mainly refers to covalent modifications to DNA or histones without affecting
genomes, which ultimately lead to phenotypic changes in cells or organisms. Given the …

Hepatocellular Carcinoma (HCC) is the most frequent malignant tumor of the liver, but its
prognosis is poor. Histone acetylation is an important epigenetic regulatory mode that …

Background Hepatocellular carcinoma (HCC) is a major public health problem in humans.
The imbalance of mitochondrial function has been discovered to be closely related to the …

Establishing structure–activity relationships (SAR) for privileged pharmacophores, such as
the indole scaffold, is a key step in the early stages of drug discovery. Herein, we report the …

In developing new cancer medications, attention has been focused on novel epigenetic
medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer …

Histone deacetylase inhibitors (HDACi) are emerging as anti-hepatocellular carcinoma
(HCC) agents. However, the molecular mechanisms underlying HDACi-induced …

Uncontrolled inflammation is a salient factor in multiple chronic inflammatory diseases and
cancers. In this review, we provided an in-depth analysis of the relationships and distinctions …

杨润1 综述, 乔佳月1, 王铎蓉1, 谭千桦2, 刘欢3, 王琳2△ 审校(1. 西安医学院第一临床医学院,
陕西西安710021; 2. 西安医学院医学技术学院, 陕西西安710021; 3. 西安医学院基础与转化医学 …

Hepatocellular cancer (HCC) progression is facilitated by gene-silencing chromatin histone
hypoacetylation due to histone deacetylases (HDACs) activation. However, inhibiting …