Mechanochemistry for synthesis
Mechanochemical solvent‐free reactions by milling, grinding or other types of mechanical
action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers …
action have emerged as a viable alternative to solution chemistry. Mechanochemistry offers …
Towards medicinal mechanochemistry: evolution of milling from pharmaceutical solid form screening to the synthesis of active pharmaceutical ingredients (APIs)
This overview highlights the emergent area of mechanochemical reactions for making active
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
pharmaceutical ingredients (APIs), and covers the latest advances in the recently …
Supramolecular concepts and new techniques in mechanochemistry: cocrystals, cages, rotaxanes, open metal–organic frameworks
T Friščić - Chemical Society Reviews, 2012 - pubs.rsc.org
Mechanochemical reactions effected by milling or grinding are an attractive means to
conduct chemical reactions dependent on molecular recognition and to systematically …
conduct chemical reactions dependent on molecular recognition and to systematically …
NMR crystallography of molecular organics
P Hodgkinson - Progress in Nuclear Magnetic Resonance …, 2020 - Elsevier
Developments of NMR methodology to characterise the structures of molecular organic
structures are reviewed, concentrating on the previous decade of research in which density …
structures are reviewed, concentrating on the previous decade of research in which density …
Barbituric acids as a useful tool for the construction of coordination and supramolecular compounds
In spite of its impressive record in medicinal chemistry, the role of barbituric acid H 3 BA
(pyrimidine-2, 4, 6 (1H, 3H, 5H)-trione) in coordination, organometallic and supramolecular …
(pyrimidine-2, 4, 6 (1H, 3H, 5H)-trione) in coordination, organometallic and supramolecular …
The relevance of crystal forms in the pharmaceutical field: sword of damocles or innovation tools?
This review is aimed to provide to an “educated but non-expert” readership and an overview
of the scientific, commercial, and ethical importance of investigating the crystalline forms …
of the scientific, commercial, and ethical importance of investigating the crystalline forms …
From unexpected reactions to a new family of ionic co-crystals: the case of barbituric acid with alkali bromides and caesium iodide
D Braga, F Grepioni, L Maini, S Prosperi… - Chemical …, 2010 - pubs.rsc.org
Pressing solid barbituric acid with KBr to prepare samples for IR spectroscopy leads to the
formation of an ionic co-crystal, in which the co-former is a classical ionic salt; co-crystal …
formation of an ionic co-crystal, in which the co-former is a classical ionic salt; co-crystal …
A rough guide to molecular solid solutions: design, synthesis and characterization of mixed crystals
M Lusi - CrystEngComm, 2018 - pubs.rsc.org
Crystalline solid solutions are long-known solid phases that enable the fine tuning of a
material's structure and properties. Some of them, like metal alloys, have been employed in …
material's structure and properties. Some of them, like metal alloys, have been employed in …
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
PF Chan, V Srikannathasan, J Huang, H Cui… - Nature …, 2015 - nature.com
New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA
topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by …
topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by …
The growing world of crystal forms
D Braga, F Grepioni, L Maini - Chemical Communications, 2010 - pubs.rsc.org
Engineering crystal properties by a choice of adequate molecular building blocks has to
cope with the fact that a given molecule can be isolated in many, at times very many, solid …
cope with the fact that a given molecule can be isolated in many, at times very many, solid …