The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Abstract tRNA-derived small RNAs (tsRNA) are a recently identified family of non-coding
RNA that have been associated with a variety of cellular functions including the regulation of …

Perfectly accurate translation of mRNA into protein is not a prerequisite for life. Resulting
from errors in protein synthesis, mistranslation occurs in all cells, including human cells. The …

tRNAs undergo an extensive maturation process including posttranscriptional modifications
that influence secondary and tertiary interactions. Precursor and mature tRNAs lacking key …

All tRNAs are extensively modified, and modification deficiency often results in growth
defects in the budding yeast Saccharomyces cerevisiae and neurological or other disorders …

Massively parallel, quantitative measurements of biomolecular activity across sequence
space can greatly expand our understanding of RNA sequence-function relationships. We …

To develop a system for conditional amino acid misincorporation, we engineered tRNAs in
the yeast Saccharomyces cerevisiae to be substrates of the rapid tRNA decay (RTD) …

Transfer RNAs (tRNAs) are well-known for their essential function in protein synthesis.
Recent research has revealed a diverse range of chemical modifications that tRNAs …

Because ambient temperature affects biochemical reactions, organisms living in extreme
temperature conditions adapt protein composition and structure to maintain biochemical …