Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to
become the only drug of choice for treatment of human schistosomiases, due to high …

Lung cancer is treated with many conventional therapies, such as surgery, radiation, and
chemotherapy. However, these therapies have multiple undesirable side effects. To bypass …

Cancer drug resistance leading to therapeutic failure in the treatment of many cancers
encompasses various mechanisms and may be intrinsic relying on the patient's genetic …

Regardless of advances in detection and treatment, breast cancer affects about 1.5 million
women all over the world. Since the last decade, genome-wide association studies (GWAS) …

DNA repair confers the resistance of tumor cells to DNA‐damaging anticancer therapies,
while how reprogrammed metabolism in tumor cells contributes to such process remains …

Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …

Non-coding RNAs are important regulators of gene expression and transcription. It is well
established that impaired non-coding RNA expression especially the one of long non …

To overcome the intrinsic resistance of cancer cells to apoptotic stimuli, we designed and
synthesized approximately 50 novel β-carbolines structurally related to harmine. Harmine is …

The cell cycle of eukaryotic cells varies greatly from species to species and tissue to tissue.
Since an erroneous control of the cell cycle can have disastrous consequences for cellular …

One of the major causes of failure in chemotherapy for patients with human chronic
myelogenous leukemia (CML) is the acquisition of multidrug resistance (MDR). MDR is often …