Metabolic alterations have been observed in many cancer types. The deregulated
metabolism has thus become an emerging hallmark of the disease, where the metabolism is …

After undergoing metabolic reprogramming, tumor cells consume additional glutamine to
produce amino acids, nucleotides, fatty acids, and other substances to facilitate their …

Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that
activates MTORC1. The AMPK-MTORC1 signaling axis is a key regulator of cell growth and …

The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are
crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed …

CAR T cells are widely applied for relapsed hematological cancer patients. With six
approved cell therapies, for Multiple Myeloma and other B-cell malignancies, new insights …

Rare subpopulations of cancer stem cells (CSCs) have the ability to self-renew and are the
primary driving force behind cancer metastatic dissemination and the preeminent hurdle to …

Rapid pericarp browning results in a short shelf life of postharvest litchi fruit. In this study, the
impact of fluopyram (Flu) on litchi pericarp browning and possible mechanisms were …

Mass spectrometry imaging vows to enable simultaneous spatially resolved investigation of
hundreds of metabolites in tissues, but it primarily relies on traditional ion images for non …

Asparagine (Asn) and enzymes that catalyze the metabolism of Asn have been linked to the
regulation and propagation of colorectal cancer (CRC). Increased Asn and asparagine …

Over the past two decades, researchers have revealed the crucial functions of glutamine in
supporting the hyperproliferation state of cancer cells. Glutamine acts on maintaining high …