The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …

Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding
sequences, and therefore they are not expected to change the function of the protein in …

The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …

The drug efflux pump P‐glycoprotein (P‐gp) plays an important role in the function of the
blood–brain barrier by selectively extruding certain endogenous and exogenous molecules …

Background Serious bleeding events have been frequently described in patients taking
direct oral anticoagulants (DOAC). In secondary analyses of phase 3 trials, DOAC plasma …

Palbociclib, ribociclib, and abemaciclib belong to the third generation of cyclin-dependent
kinases inhibitors (CDKis), an established therapeutic class for advanced and metastatic …

Context Patients with primary adrenal insufficiency (Addison's disease) receive more
glucococorticoids than the normal endogenous production, raising concern about adverse …

Methadone is a mu-opioid receptor agonist used for treating opiate dependence. The range
of effective methadone doses is broad. Part of the large inter-individual variability in efficacy …

ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …